CINCINNATI -- Andrew McCutchen tied the game with a solo homer in the ninth inning Saturday night, then connected again in the 11th inning, rallying the struggling Pittsburgh Pirates to a 6-5 victory over the Cincinnati Reds.
The Pirates blew a four-run lead for the second straight night, but managed to come back behind McCutchen, who has more homers against Cincinnati than anyone else since 2009.
He tied it 5 in the ninth off Jonathan Broxton, filling in the closer's role because Aroldis Chapman had pitched four days in a row. He hit his 17th homer with two outs in the 11th off J.J. Hoover (1-7) for his ninth career multihomer game.
Left-hander Justin Wilson (3-1) escaped a bases-loaded threat in the 10th with the help of right fielder Gregory Polanco, who threw Ramon Santiago out at the plate as he tried to score on Jay Bruce's single.
Jeanmar Gomez pitched the 11th for his first career save.
The Reds won the series opener 6-5 by rallying in the eighth inning against All-Star reliever Tony Watson, overcoming a four-run deficit. They pulled out of a four-run deficit again on Saturday but couldn't finish it off.
McCutchen has 20 career homers against Cincinnati, the most by any player in the majors since 2009. He's hit six of them this season, including three during the first two games of the series.
The Reds slipped to 7-3 on their 11-game homestand, remaining 1 1/2 games behind NL Central co-leaders Milwaukee and St. Louis. Cincinnati is 8-4 against the Pirates this season.
Pittsburgh is 2-4 on a trip to St. Louis and Cincinnati. The Pirates gave up two game-ending homers in St. Louis and blew a four-run lead in the series opener, a 6-5 Reds win.
The Reds got in position to win it with a pair of homers.
Chris Heisey batted for Mike Leake in the sixth and hit a two-run shot off Charlie Morton. Todd Frazier -- who will participate in the All-Star home run derby next week -- completed the comeback with a three-run shot off Morton, who had given up a total of six homers coming into the game.