Jorge De La Rosapitched six effective innings for his 15th win. Helton's 28th career multihomer game and first since 2011 left him one hit shy of 2,500.
The first of his two three-run homers came in the fourth off Bronson Arroyo(13-10) roughed up for six runs and nine hits over 3 1/3 innings in his shortest outing of the season. He issued a one-out walk in the first, ending a 30-inning string without one, and had his four-game winning streak snapped.
Helton homered again in the seventh off reliever Logan Ondrusek, his 11th of the season.
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