Profar homered off Reds starter Homer Bailey in the third and ranks second in the Cactus League with 11 RBIs.
Bailey gave up two runs on three hits, while striking out five and walking none.
The Rangers seized the lead in the fifth on Elvis Andrus' two-out, two-run single.
Adam Rosales contributed a two-run single in the Rangers' four-run fourth off Curtis Patch.
The Reds meet the Giants Tuesday afternoon with Tony Cingrani the starter. Coverage begins at 3 35pm on 700 WLW.